目的：研究ＩＬ－１、ＩＬ－６和活化枯否细胞（Ｋｃ）产物对约氏疟原虫红外期（ＥＥＦ）发育的影响。方法：大鼠腹腔注射ＩＬ－１、ＩＬ－６或合用，３ｈ后接种子孢子（Ｓｐ），４２ｈ后观察ＥＥＦ发育情况；建立大鼠肝细胞－约氏疟原虫体外培养模型，Ｓｐ接种后２ｈ加ＩＬ－１、ＩＬ－６及激活后Ｋｃ培养上清，观察对ＥＥＦ发育的影响。结果：ＩＬ－１组、合用组Ｓｐ发育率明显降低，ＩＬ－６组无明显下降；ＩＬ－１、ＩＬ－６明显抑制培养的ＥＥＦ发育；激活Ｋｃ培养上清也可抑制ＥＥＦ发育，ＥＥＦ成熟度低、体积小。结论：ＩＬ－１、ＩＬ－６在体内外和接种Ｓｐ前后均可抑制ＥＥＦ的发育 Objective: To investigate the effects of IL-1, IL-6 and Kc on the development of EEF in P. yoelii. Methods: The rats were injected intraperitoneally with IL-1 and IL-6, and sporocysts were inoculated 3 hours later. The development of EEF was observed after 42 hours. The model of rat hepatocytes-P. yoelii was established in vitro, Add IL-1, IL-6 and activated Kc culture supernatant to observe the impact of EEF development. Results: The rate of Sp development in IL-1 group and combination group was significantly lower than that in IL-6 group, IL-1 and IL-6 significantly inhibited the development of EEF, and the activation of Kc culture supernatant also inhibited EEF development and EEF maturation Low degree, small size. Conclusion: Both IL-1 and IL-6 can inhibit the development of EEF in vitro and in vivo before and after Sp inoculation