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目的:分析遗传学异常对侵袭性套细胞淋巴瘤预后的影响。方法:回顾性分析50例伴外周血及骨髓侵犯的套细胞淋巴瘤患者资料。使用荧光原位杂交方法检测患者D13S25/13q14、ATM/11q22、P53/17p13和IGH/CCND1/t(11;14)共4种DNA探针,分析遗传学相关性及预后的影响。结果:Del 13q、Del 11q和Del 17p的发生率分别为36.0%、18.0%和34.0%。单因素分析显示MIPI预后评分系统,Del 13q和Del 17p均为无进展生存的影响因素,而Del 13q、Del 17p和不同治疗方案为总生存的影响因素。结论:P53缺失在套细胞淋巴瘤患者中作为常见的细胞突变,在患者预后中对无进展生存和总生存具有独立的不良预后影响。
Objective: To analyze the influence of genetic abnormalities on the prognosis of invasive mantle cell lymphoma. Methods: The data of 50 patients with mantle cell lymphoma invading peripheral blood and bone marrow were retrospectively analyzed. Four DNA probes, D13S25 / 13q14, ATM / 11q22, P53 / 17p13 and IGH / CCND1 / t (11; 14) were detected by fluorescence in situ hybridization to analyze the genetic correlation and prognosis. Results: The incidences of Del 13q, Del 11q and Del 17p were 36.0%, 18.0% and 34.0%, respectively. Univariate analysis showed that the MIPI prognostic score system, Del 13q and Del 17p were all the influencing factors of progression-free survival, whereas Del 13q, Del 17p and different treatment regimens were the influencing factors of overall survival. CONCLUSIONS: P53 deletion is a common cellular mutation in patients with mantle cell lymphoma and has an independent adverse prognostic impact on progression-free survival and overall survival in patient outcomes.