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目的通过观察人类白细胞抗原G(HLA-G)在胎膜早破患者与正常妊娠胎盘组织及外周血中的表达差异,探讨HLA-G在母胎耐受中的意义。方法分组:选取本院2010年5月～10月行剖宫产分娩产妇40例,其中胎膜早破组20例(实验组),正常产妇组20例(对照组)。采用流式细胞术检测两组产妇外周血及胎盘组织的HLA-G+的表达情况,比较两组表达差异。结果胎膜早破患者胎盘组织中HLA-G+表达显著低于正常妊娠组,差异有统计学意义(P<0.05)。结论 HLA-G+在胎盘中的低表达可能与胎膜早破的发生有关,对于母胎耐受的维持有意义。
Objective To investigate the expression of HLA-G in maternal fetal tolerance by observing the expression of human leukocyte antigen G (HLA-G) in premature rupture of membranes and normal pregnant placenta tissues and peripheral blood. Methods: 40 cases of cesarean delivery in our hospital from May to October 2010 were selected, including 20 cases of premature rupture of membranes (experimental group) and 20 cases of normal maternal group (control group). Flow cytometry was used to detect the expression of HLA-G + in peripheral blood and placenta of the two groups, and the differences between the two groups were compared. Results The expression of HLA-G + in placenta of premature rupture of membranes was significantly lower than that in normal pregnancy (P <0.05). Conclusion The low expression of HLA-G in placenta may be related to the occurrence of premature rupture of membranes and is meaningful for the maintenance of maternal-fetal tolerance.