硝苯吡啶(Nifedipine)对缓解稳定型和变异型心绞痛很有效。其作用据认为是通过阻滞细胞膜的钙离子流,从而放松血管平滑肌。对心肌细胞亦有类似作用,电压钳实验显示它能使心室肌细胞的高原相移到较小的正值电压,缩短动作电位时间和产生强力的负性肌力作用,以及阻滞“缓慢流入离子流”。抑制心肌细胞的缓慢流入离子流有可能消除由某些机制包括折返、异常自律性及触发反应等所引起的心律失常。本文旨在研究硝苯吡啶对心肌细胞电活性的影响。 Nifedipine is effective in relieving stable and variant angina. Its role is believed to be by blocking the cell membrane calcium flux, thereby relaxing vascular smooth muscle. Voltage-clamp experiments have shown that it can phase shift the plateaus of ventricular myocytes to smaller positive voltages, shorten the duration of action potentials and produce strong negative inotropic effects, as well as block “slow influx Ion flow. ” Inhibiting the slow flow of cardiomyocytes into the ion stream may eliminate arrhythmias caused by certain mechanisms including reentry, abnormal self-regulation, and triggering reactions. This article aims to study the effect of nifedipine on cardiomyocyte electrical activity.