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目的探讨不孕妇女生殖道支原体感染及耐药分析。方法对320例就诊的不孕妇女(不孕组)进行支原体培养和药敏试验,另选择80例同期早孕健康妇女作对照组。结果不孕组妇女的支原体感染率(35.3%)明显高于对照组(12.5%)(χ2=15.64,P<0.01)。支原体对四环素、多西环素以及米诺环素敏感率>65%;对红霉素、阿奇霉素、克拉霉素以及罗红霉素敏感率<50%,对交沙霉素的敏感率为75.2%;对喹诺酮类抗生素诺氟沙星、氧氟沙星、左氧氟沙星以及司帕沙星耐药率均>75%。结论支原体感染,特别UU感染是引起不孕的主要原因之一。四环素类抗生素和交沙霉素可作为本地区支原体治疗的首选药物。
Objective To investigate the genital mycoplasma infection and drug resistance in infertile women. Methods 320 cases of infertile women (infertility group) for mycoplasma culture and drug sensitivity test, another 80 cases of early pregnancy healthy women as control group. Results The prevalence of mycoplasma in infertile women (35.3%) was significantly higher than that in the control group (12.5%) (χ2 = 15.64, P <0.01). Mycoplasma tetracycline, doxycycline and minocycline susceptibility> 65%; to erythromycin, azithromycin, clarithromycin and roxithromycin susceptibility was <50%, the sensitivity rate of josamycin 75.2 %; Quinolone antibiotics norfloxacin, ofloxacin, levofloxacin and sparfloxacin resistance rates were> 75%. Conclusion Mycoplasma infection, especially UU infection is one of the main causes of infertility. Tetracycline antibiotics and josamycin can be used as the drug of choice for mycoplasma treatment in the region.