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目的 探讨脑胶质瘤组织中耐药相关基因MGMT、erbB2的表达及临床意义.方法 采用RT-PCR法对42例脑胶质瘤标本中MGMT、erbB2 mRNA进行测定.结果 MGMT和erbB2在脑胶质瘤标本中的阳性表达率分别为45.2%和61.9%,两者有极显著相关性(P<0.01).结论 MGMT和erbB2在脑胶质瘤中均有较高表达,对合理选择胶质瘤化疗药物有一定临床意义.“,”Objective To study the expression and significance of MGMT and erbB2 in human glioma. Methods RT-PCR method was used to determine the mRNA levels of MGMT and erbB2 gene in 42 clinical glioma specimens. Results The expression rates of MGMT and erbB2 in human glioma were 45. 2% and 61. 9%, respectively. The expression of MGMT was closely correlated to that of erbB2 (P<0. 01). Conclusion MGMT and erbB2 are all overexpressed in human gliomas, which is helpful to the drug selection for chemotherapy.