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我们自1985年起先后使用诺氟沙星(NFLX)、依诺沙星(ENX)、培氟沙星(PFLX)、环丙沙星(CPLX)治疗各种急性细菌感染1071例。所有病例年龄在14～65岁,无肝、肾或其它系统病史,药物剂量及疗程均按常规使用。从临床症状、体征及常规化验看出四种药物的毒副反应以消化道症状如纳差、(口恶)心、胃部不适多见(8.21％),其中PFLX组更为多见。3例菌痢病人使用ENX、NFLX出现血尿,其中2例有紫癜病史和血尿史,停药后均很快好转,预后均佳。7例出现皮疹(0.7％),6例系伤寒病人,占伤寒病人11％,以PFLX组及ENX组最多,皮疹出现时间在用药后2～3天最多,多数经抗过敏处理后皮
Since 1985, we have treated 1071 acute bacterial infections with NFLX, ENX, PFLX and CPLX. All cases aged 14 to 65 years old, no liver, kidney or other system history, drug dosage and treatment are routinely used. The clinical symptoms, signs and routine tests showed that the side effects of four drugs with gastrointestinal symptoms such as anorexia, (bad heart), stomach discomfort more common (8.21%), of which PFLX group more common. 3 cases of bacillary dysentery patients using ENX, NFLX hematuria, including 2 cases of history of purpura and hematuria, withdrawal quickly improved, the prognosis are good. 7 cases showed a rash (0.7%), 6 cases of typhoid fever patients, accounting for 11% of typhoid patients, with PFLX group and ENX group up, rash appeared in the medication 2 to 3 days after most of the anti-allergic skin