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目的:观察二至丸合二仙汤联合雌激素治疗肾阴阳两虚型围绝经期综合征患者的临床疗效。方法:将120例肾阴阳两虚型的围绝经期综合征的妇女随机分为中西医结合组(治疗组,60例)和激素组(对照组,60例),分别给予二至丸合二仙汤联合雌激素治疗及雌激素替代进行治疗,观察两组有效率、卵泡刺激素(FSH)、雌二醇(E2)。结果:治疗组完全缓解30例,显效18例,有效8例,无效4例,有效率93.33%;对照组完全缓解22例,显效14例,有效8例,无效16例,有效率达73.33%。治疗组的有效率显著高于对照组,差异有统计学意义(χ2=4.320,P<0.05)。治疗组比对照组降低FSH水平能力高,能有效缓解卵巢功能下降。治疗组升高E2水平优于对照组。结论:二至丸合二仙汤联合雌激素治疗肾阴阳两虚型围绝经期综合征有显著疗效且应用简单,有效地缓解了患者的临床症状,降低了不良反应率,提高了患者的生活质量,值得在临床借鉴及推广。
Objective: To observe the clinical efficacy of Erzhi Pills combined Erxian Decoction combined with estrogen in the treatment of patients with perimenopausal syndrome of deficiency of both yin and yang. Methods: A total of 120 women with perimenopausal syndrome of deficiency of kidney, yin and yang were randomly divided into two groups (60 cases in the treatment group and 60 cases in the treatment group) and the hormone group (60 cases in the control group) Decoction combined with estrogen therapy and estrogen replacement therapy were observed, the two groups were observed, follicle stimulating hormone (FSH), estradiol (E2). Results: The treatment group completely relieved 30 cases, markedly effective in 18 cases, effective in 8 cases, ineffective in 4 cases, effective rate was 93.33%; control group completely relieved in 22 cases, markedly effective in 14 cases, effective in 8 cases, ineffective in 16 cases, effective rate was 73.33% . The effective rate of the treatment group was significantly higher than that of the control group, the difference was statistically significant (χ2 = 4.320, P <0.05). The treatment group than the control group to reduce the level of FSH, ovarian function can effectively alleviate the decline. The treatment group increased E2 levels better than the control group. Conclusion: Erzhi Pills combined Erxian Decoction combined with estrogen has a significant effect on the treatment of perimenopausal syndrome with deficiency of kidney, yin and yang and has a simple and effective method to relieve the clinical symptoms, reduce the adverse reaction rate and improve the patients’ quality of life , It is worth in the clinical reference and promotion.