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目的:探讨survivin在喉癌和下咽癌中的表达情况及与p53、bcl-2间的相互关系。方法:采用免疫组织化学SP法检测40例喉及下咽癌和10例声带息肉组织中survivin、p53及bcl-2的表达。结果:survivin、p53及bcl-2在喉癌及下咽癌中的阳性表达率分别为70.0%、57.5%和37.5%,而三者在声带息肉组织中均无表达(P<0.05)。survivin的表达随着病理分化程度的降低而增加,与临床分期、淋巴结转移成正相关(P<0.05),与年龄无关;bcl-2的表达与临床分期成负相关(P<0.05),与其他参数无关;p53的表达与各临床病理参数均无明显相关性。survivin在喉癌和下咽癌中的表达与p53的表达成正相关(P<0.05),而与bcl-2的表达无相关性(P>0.05)。结论:survivin、p53可能参与喉癌及下咽癌的发生、发展并在其中起协同作用,但bcl-2则可能是通过不同的机制参与喉癌及下咽癌的发生。
Objective: To investigate the expression of survivin in laryngeal carcinoma and hypopharyngeal carcinoma and its relationship with p53, bcl-2. Methods: The expressions of survivin, p53 and bcl-2 in 40 cases of laryngeal and hypopharyngeal carcinoma and 10 cases of vocal cord polyps were detected by immunohistochemical SP method. Results: The positive rates of survivin, p53 and bcl-2 in laryngeal carcinoma and hypopharyngeal carcinoma were 70.0%, 57.5% and 37.5% respectively, but none in vocal cord polyps (P <0.05). The expression of survivin increased with the decrease of the degree of pathological differentiation, which was positively correlated with clinical stage and lymph node metastasis (P <0.05), but not with age. The expression of survivin was negatively correlated with clinical stage (P <0.05) No correlation was found between the expression of p53 and the clinicopathological parameters. The expression of survivin in laryngeal carcinoma and hypopharyngeal carcinoma was positively correlated with the expression of p53 (P <0.05), but not with the expression of bcl-2 (P> 0.05). CONCLUSIONS: Survivin and p53 may be involved in the development and progression of laryngeal and hypopharyngeal carcinoma. However, bcl-2 may play a role in the pathogenesis of laryngeal carcinoma and hypopharyngeal carcinoma through different mechanisms.