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恶性肿瘤是严重威胁人类健康的疾病。肿瘤的转移与复发是治疗所面临的两大难题,但其机制还不清楚。肿瘤干细胞理论对此提出新的解释,其认为肿瘤中存在一小群具有自我更新和不定潜能的肿瘤细胞,可能是肿瘤转移和复发的根源。目前为止,研究人员已经在白血病、多发性骨髓瘤、乳腺癌、中枢神经系统肿瘤、肺癌分离并鉴定出了肿瘤干细胞,在胃癌和肝癌中也发现了肿瘤干细胞存在的证据。肿瘤干细胞学说的提出与证实使人类对肿瘤的转移、复发有了新的认识,必将对肿瘤转移、复发的治疗及预防产生重大影响。
Malignancy is a serious disease that threatens human health. Tumor metastasis and recurrence are two major challenges in the treatment, but the mechanism is still unclear. Cancer stem cell theory put forward a new explanation for this, which suggests that there is a small group of tumor cells with self-renewal and indefinite potential in tumors, which may be the source of tumor metastasis and recurrence. So far, researchers have isolated and identified cancer stem cells in leukemia, multiple myeloma, breast cancer, CNS tumors, lung cancer and evidence of the presence of cancer stem cells in gastric and liver cancers. The proposal and confirmation of tumor stem cell theory have made human beings have a new understanding of tumor metastasis and recurrence and will have a significant impact on the treatment and prevention of tumor metastasis and recurrence.