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本文通过共沉淀法,合成了两水亲性嵌段共聚物聚(乙烯吡咯烷酮)-b-聚(苯乙烯-alt-马来酸酐)(PVP-b-PSMA)修饰的Fe3O4磁纳米粒子。并利用动态光散射法(DLS)、X射线粉末衍射(XRD)和扫描电镜(SEM)对磁纳米粒子进行表征。结果表明,嵌段共聚物修饰的Fe3O4磁纳米粒子与纯Fe3O4磁纳米粒子比较,分布更分散,为大小均匀的球状颗粒,其粒径在100nm左右。振动样品磁强计(VSM)测试结果显示,在室温、外加磁场下,该磁纳米粒子呈现超顺磁性,其饱和磁化强度为55emuΠg。以上结果表明Fe3O4磁纳米粒子有望应用于磁靶向药物控释、热疗、酶的固定、生物分离等生物医学领域。
In this paper, Fe3O4 magnetic nanoparticles modified by poly (vinyl pyrrolidone) -b-poly (styrene-alt-maleic anhydride) (PVP-b-PSMA) were synthesized by coprecipitation method. The magnetic nanoparticles were characterized by dynamic light scattering (DLS), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The results showed that the particle size of the modified Fe3O4 magnetic nanoparticles modified with block copolymers was more dispersed than that of pure Fe3O4 magnetic nanoparticles, and their size was about 100 nm. Vibrational sample magnetometer (VSM) test results show that at room temperature, applied magnetic field, the magnetic nanoparticles showed superparamagnetism, the saturation magnetization of 55emuΠg. The above results show that Fe3O4 magnetic nanoparticles are expected to be used in biomedical fields such as controlled release of magnetic targeting drugs, hyperthermia, immobilization of enzymes, and biological separation.