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目的通过对比托拉塞米和呋塞米的利尿作用,探讨托拉塞米在中、重度充血性心力衰竭治疗中的短期应用价值。方法45例中、重度充血性心力衰竭患者,按治疗方法不同随机分成2组,托拉塞米组给予托拉塞米,呋塞米组给予呋塞米,治疗7 d,记录2组患者治疗前及治疗后24 h尿量、体重、血电解质水平及心功能的分级。结果治疗后24 h,托拉塞米组的尿量明显增加,日尿量(2 158±825.3)ml,多于呋塞米组(1 892±768.5)ml(P<0.05)。治疗7 d后,2组体重均明显下降,临床心功能均明显改善,组间比较,体重及心功能差异均无统计学意义(P均>0.05)。结论短期应用托拉塞米疗效肯定,利尿作用更强,可迅速改善心功能。
Objective To compare the diuretic effect of torsemide and furosemide to explore the short-term value of torsemide in the treatment of moderate and severe congestive heart failure. Methods Forty-five patients with severe congestive heart failure were randomly divided into 2 groups according to the different treatment methods. Torsemide was given to torsemide and furosemide was given to furosemide for 7 days. Two groups of patients were treated Urine volume, body weight, blood electrolytes and cardiac function at 24 h before and after treatment. Results The urine volume of torsemide group increased significantly (2458 ± 825.3) ml more than that of furosemide group (1892 ± 768.5) ml (P <0.05) 24 hours after treatment. After 7 days of treatment, body weight of both groups decreased significantly and clinical cardiac function improved significantly. There was no significant difference in weight and heart function between two groups (all P> 0.05). Conclusion Short-term application of torsemide efficacy is positive, more diuretic effect, can quickly improve heart function.