铜是人类必需的微量元素之一,临床缺铜并不多见,但孕妇易有铜的缺乏。本实验通过缺铜的大鼠动物模型,从妊娠、哺乳及断奶后仔鼠的临床观察、实验室数据及脑的病理变化等来验证母鼠缺铜对仔鼠发育的影响。 采用纯种Wistar母鼠自受孕第一日开始随机分两组:缺铜组和正常对照组。经妊娠、分娩至哺乳期末(即仔鼠生后30日)为实验第一阶段,两组的母鼠及各1/3仔鼠处死,测血铜、组织 Copper is one of the trace elements essential to human beings, the clinical lack of copper is rare, but pregnant women prone to lack of copper. In this experiment, the effects of copper deficiency on the development of offspring were examined by animal model of copper deficient rats from the clinical observation, laboratory data and pathological changes of the pregnant, nursing and post-weaning offspring. Pure Wistar female rats were randomly divided into two groups from the first day of pregnancy: copper deficiency group and normal control group. After pregnancy, childbirth until the end of lactation (that is, 30 days after pups born) for the first phase of the experiment, two groups of female rats and one third of the pups were sacrificed to measure blood copper, tissue