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目的观察奥美拉唑联合铝碳酸镁治疗胆囊切除术后胆汁反流性胃炎对患者胃肠激素、血管活性肠肽(VIP)及血清IL-6水平的影响。方法将胆囊切除术后胆汁反流性胃炎患者240例随机分为研究组和对照组,每组120例。对照组给予铝碳酸镁治疗,研究组给予奥美拉唑联合铝碳酸镁治疗。比较2组患者治疗前后血清胃肠激素、VIP及IL-6水平的变化。结果治疗后2组患者胃动素水平高于治疗前,且研究组高于对照组(P<0.05);胃泌素水平、VIP及IL-6水平均低于治疗前(P<0.05),且研究组低于对照组(P<0.05)。结论奥美拉唑联合铝碳酸镁治疗胆囊切除术后胆汁反流性胃炎疗效显著,可显著改善患者胃肠激素、VIP及IL-6水平,值得临床推广应用。
Objective To observe the effects of omeprazole combined with magnesium aluminum carbonate on the gastrointestinal hormones, vasoactive intestinal peptide (VIP) and serum IL-6 in patients with bile-reflux gastritis after cholecystectomy. Methods 240 patients with bile reflux gastritis after cholecystectomy were randomly divided into study group and control group, with 120 cases in each group. The control group was given magnesium aluminum carbonate, and the study group was given omeprazole combined with magnesium aluminum carbonate. The changes of serum gastrointestinal hormones, VIP and IL-6 levels before and after treatment were compared between the two groups. Results After treatment, the level of motilin in both groups was higher than that before treatment, and the study group was higher than the control group (P <0.05). The levels of gastrin, VIP and IL-6 were lower than those before treatment (P <0.05) And the research group was lower than the control group (P <0.05). Conclusion Omeprazole combined with magnesium aluminum carbonate in the treatment of bile reflux gastritis after cholecystectomy significant effect, can significantly improve the level of gastrointestinal hormone, VIP and IL-6, worthy of clinical application.