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目的 探讨喷他佐辛联合左旋布比卡因在硬膜外麻醉中的临床应用效果.方法 选取武汉市普爱医院2014年1月至2015年1月收治的择期采用硬膜外麻醉的手术患者150例,分为A、B、C三组,每组50例,A组使用0.75%左旋布比卡因10ml加喷他佐辛15mg,B组使用0.75%左旋布比卡因10 ml加喷他佐辛7.5mg,C组使用0.75%左旋布比卡10ml,比较三组患者不良反应、感觉阻滞效果、运动阻滞效果、起效时间及辅助用药情况.结果 A组总不良反应人数为4人,B组为5人,均少于C组不良反应人数9人,差异有统计学意义(P<0.05).A组持续镇痛时间为(105.4±8.2)min,到达T10阻滞平面所需时间为(9.6±5.3)min,均优于B、C两组(P<0.05);A组患者运动阻滞Bromage平均得分为(2.11±0.11)分,高于B、C组的(1.68±0.09)和(1.12±0.12)分,差异有统计学意义(P<0.05).A、B、C三组患者下肢阻滞的起效时间分别为(4.5±1.9)、(5.2±2.1)、(7.3±2.0)min,辅助药物应用情况比例分别为8.00%、14.00%、24.00%,三组比较差异均有统计学意义(P<0.05).结论 喷他佐辛联合左旋布比卡因用于硬膜外麻醉可以有效地减少麻醉阻滞到达阻滞平面所用时间,降低起效时间,减少辅助药物的使用与并发症的发生.“,”Objective To study the clinical application of Pentazocine combining with Levobupivacaine for epidural anesthesia. Methods 150 cases of surgical patients applying epidural anesthesia and admitted in this hospital from January,2014 to January,2015 were selected and divided into group A,group B and group C. 10 ml of 0.75% Levobupivacaine plus 15 mg of Pentazocine were applied in group A;10 ml of 0.75% Levobupivacaine with 7.5 mg of Pentazocine were applied in group B;10 ml of 0.75% Levobupivacaine was applied in group C. The condition of adverse reaction, sensory block effect,motor block effect, initial effect time and supplementary medicines were compared.Results The number of patients with adverse reactions in group A was 4,group B was 5,and group C was 9.The difference between group A and B was not significant,while the difference between group B and C was significant(P<0.05). In group A,analgesia duration was (105.4±8.2) min,reached the highest block plane time was (9.6±5.3) min,and was superior to group B and C(P<0.05). The average of Bromage scored of group A was (2.11±0.11) points,significantly higher than those in group B and C (P<0.05). The onset time of lower extremity of patients with A,B and C group were(4.5±1.9),(5.2±2.1),(7.3±2.0)min, The proportion of auxiliary drug use was 8.00%,14.00%,24.00%, respectively,The difference between the three groups was statistically significant (P<0.05).Conclusion Pentazocine joint Levobupivacaine for epidural anesthetic block can effectively reduce the time spent to reach the block plane,reducing the onset time,reduce the incidence of secondary drug use and complications.