肉毒碱是一种广泛存在于机体内的氨基酸。本文报告了人工合成d,1-肉毒碱盐酸盐对麻醉猫衰心及离体豚鼠心脏功能的影响。用缓慢均速静注戊巴比妥钠引起猫急性心衰。给心衰猫静注肉毒碱50mg/kg/min共5分钟,给药后BP、LVP及LV(dp/dt)max均明显增加,与给药前相比分别增加288±124％,172±59％和404±127％(P<0.001)。与对照组比较亦均有显著差异。与此同时,心率稍减慢,GVP及LVEDP轻度 Carnitine is a widely found amino acid in the body. This article reports the effects of artificially synthesized d, 1-carnitine hydrochloride on heart failure in anesthetized cats and heart function in isolated guinea pigs. Slow intravenous injection of sodium pentobarbital slowly induced cat acute heart failure. The carnitine 50 mg / kg / min was intravenously injected into heart failure cats for 5 minutes. After administration, the BP, LVP and LV (dp / dt) max were significantly increased, which were increased by 288 ± 124% ± 59% and 404 ± 127% (P <0.001). Compared with the control group also had significant differences. In the meantime, heart rate slowed slightly, with mild GVP and LVEDP