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目的探讨慢性乙型肝炎患者血清乙型肝炎病毒基因(HBV-DNA)与e抗原含量的关系。方法 379例慢性乙型肝炎患者,均采取定量聚合酶链反应(PCR)、水解探针Taqman法予以检测,分析血清HBV-DNA含量与e抗原相关性。结果 HBeAg(+)、E系统双阳、HBeAg(-)中HBV-DNA、HBeAg含量进行两两对比,差异均具有统计学意义(P<0.05)。轻、重度慢性乙型肝炎HBV-DNA含量对比,差异有统计学意义(P<0.05)。结论慢性乙型肝炎患者血清HBV-DNA和HBeAg具有一定相关性,病情加重,HBV-DNA含量下降。
Objective To investigate the relationship between serum hepatitis B virus (HBV-DNA) and e antigen in chronic hepatitis B patients. Methods 379 patients with chronic hepatitis B were detected by quantitative polymerase chain reaction (PCR) and Taqman method. The correlation between serum HBV DNA level and e antigen was analyzed. Results HBV-DNA and HBeAg in HBeAg (+), E-system Shuangyang and HBeAg (-) were significantly different (all P <0.05). The levels of HBV-DNA in mild and severe chronic hepatitis B were significantly different (P <0.05). Conclusion Serum HBV-DNA and HBeAg in patients with chronic hepatitis B have a certain correlation, the condition is aggravated and the content of HBV-DNA is decreased.