论文部分内容阅读
为探讨CD44与胃肠道肿瘤的关系，应用流式细胞免疫技术分析了52例胃肠道恶性肿瘤、29例胃肠道良性肿瘤患者外周血及瘤体中CD44的含量。并与正常人对照。发现恶性肿瘤外周血及肿瘤细胞CD44含量明显高于正常人（P<0．001）和良性肿瘤（P<0．001）。后两者外周血CD44含量相差不大（P>0．05）。已有转移者外周血及瘤组织中CD44含量明显高于未转移者（P<0．01）。无转移者根治性手术后外周血CD44含量迅速下降至正常，而已有转移者无论何种手术其CD44含量变化不大，表明CD44可用作胃肠道肿瘤的转移指标，并在早期诊断、治疗方案的选择、疗效观察及预后评估方面有重要临床意义。
To investigate the relationship between CD44 and gastrointestinal tumors, flow cytometric analysis was used to analyze the levels of CD44 in 52 cases of gastrointestinal cancer and 29 cases of gastrointestinal benign tumors. And compared with normal people. The levels of CD44 in peripheral blood and tumor cells of malignant tumors were significantly higher than those in normal controls (P<0.001) and benign tumors (P<0.001). The levels of CD44 in peripheral blood of the latter two groups were not significantly different (P>0.05). The content of CD44 in peripheral blood and tumor tissues of those with metastasis was significantly higher than those without metastasis (P<0.01). The CD44 content in the peripheral blood of patients with no metastasis rapidly decreased to normal, but the CD44 content of the patients with existing metastasis no matter what kind of surgery has little change, indicating that CD44 can be used as a metastasis index of gastrointestinal cancer, and early diagnosis and treatment The choice of the protocol, the observation of the efficacy, and the evaluation of the prognosis have important clinical implications.