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为研究Ｇ蛋白变化与慢性缺氧性肺动脉高压发生的关系，本文应用核酸分子杂交方法及免疫组织化学法，测定了慢性缺氧性肺动脉高压大鼠肺组织Ｇ蛋白（Ｇα０）ｍＲＮＡ水平及其在肺组织中的分布。结果发现：Ｇα０分布于肺动脉壁肌层的神经纤维中，慢性缺氧可使Ｇα０阳性神经纤维数目明显增多，而且肺组织中Ｇα０ｍＲＮＡ水平为对照组的１．６８倍。结果提示：慢性缺氧性肺动脉高压发病过程可能有通过Ｇα０起作用的神经机制参与
In order to study the relationship between G protein changes and the occurrence of chronic hypoxic pulmonary hypertension, we used the nucleic acid hybridization and immunohistochemical methods to determine the G protein (Gα0) mRNA expression in lung tissue of chronic hypoxic pulmonary hypertension Distribution in lung tissue. The results showed that: Gα0 distributed in the muscle fibers of the pulmonary artery wall of the nerve fibers, chronic hypoxia Gα0 positive fibers can significantly increase the number of fibers, and lung tissue Gα0 mRNA levels 1.68 times the control group. The results suggest that the pathogenesis of chronic hypoxic pulmonary hypertension may be involved in the neural mechanisms through Gα0