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活性氧(ROS)是具有氧化还原潜能的氧衍生物。近年发现ROS参与了血管功能的调节。促氧化能力超过抗氧化能力称为氧化应激。氧化应激介导很多心血管疾病的血管损伤和炎症。动物和人类高血压常伴随ROS增加。高血压动物模型可以通过减少ROS来减轻血管重建、改善内皮功能、缓解炎症、降低血压。这些证据为高血压防治提供了新的研究领域。
Reactive oxygen species (ROS) are oxygen derivatives with redox potential. In recent years, ROS is involved in the regulation of vascular function. Pro-oxidant capacity over antioxidant capacity is called oxidative stress. Oxidative stress mediates vascular injury and inflammation in many cardiovascular diseases. Animal and human hypertension is often accompanied by an increase in ROS. Hypertensive animal model can reduce vascular revascularization by reducing ROS, improve endothelial function, relieve inflammation and lower blood pressure. These evidences provide new areas of research for the prevention and treatment of hypertension.