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2-芳基吡啶和氰酸钾(2倍摩尔量),在Cu(OAc)_2·H_2O(2倍摩尔量)的催化和K_2S_2O_8(1.5倍摩尔量)、特戊酸(1倍摩尔量)的共同氧化加成下,140℃微波反应18 h,生成相应2-(2-乙酰胺基芳基)吡啶。13例收率31%~83%。芳基含供电子基或对位取代时收率较高。
2-arylpyridine and potassium cyanate (2-fold molar amount) in the presence of Cu (OAc) 2 · H 2 O (2 times molar amount) catalyzed by K 2 S 2 O 8 (1.5 times molar amount) Under the co-oxidation addition reaction, the reaction was carried out at 140 ℃ for 18 h under microwave irradiation to form the corresponding 2- (2-acetamidoaryl) pyridine. 13 cases of the yield of 31% to 83%. Aryl groups with electron-donor or para-substituted higher yield.