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作者最近报道了一群表面有T_3、T_4抗原的人淋巴细胞,能裂解感染斑疹伤寒组立克次体的靶细胞。这种效应细胞称为淋巴因子激活杀伤细胞(LAK),可以通过斑疹伤寒组立克次体抗原刺激有免疫者的外周血单个核细胞或通过自细胞介素-2(IL-2)刺激有免疫或无免疫者的外周血单个核细胞的生成。 LAK在体外可裂解各种肿瘤细胞,在体内可抑制肿瘤的生长。但对LAK裂解感染胞内病原体的靶细胞则尚未见报道。为进一步了解LAK的裂解过程和效应细胞的表面抗原,作者采用各种抗淋巴细胞表面抗原的单克隆抗体(简称单抗,有OKT_3、
The authors recently reported that a group of human lymphocytes with T_3 and T_4 antigens on their surface could lyse target cells infected with rickettsia in the typhus group. This effector cell, known as lymphokine-activated killer (LAK) cells, stimulates the peripheral blood mononuclear cells of the immunized by Racl typhimurium or stimulated by interleukin-2 (IL-2) Generation of peripheral blood mononuclear cells with or without immunization. LAK can lyse a variety of tumor cells in vitro and can inhibit tumor growth in vivo. However, LAK lytic target cells infected with intracellular pathogens have not been reported. To further understand the process of LAK lysis and surface antigen of effector cells, the authors used a variety of monoclonal antibodies against lymphocyte surface antigen (referred to as monoclonal antibody, OKT_3,