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目的 :研究三七注射液对家兔失血性休克晚期的治疗作用及其机制。方法 :将 16只家兔随机分两组 ,制备失血性休克晚期模型 ,对照组 :休克 12 0min后 ,回输 2倍于失血量的生理盐水和全部失血。治疗组 :扩容开始时 ,静脉滴入三七 (PNS) 15 0mg/kg ,扩容方法同对照组 ,通过对休克前 ,休克 6 0min ,12 0min再灌注 30min ,6 0min和 12 0min所抽静脉血样的酸性磷酸酶 (ACP)、镁 (Mg2 + )、丙二醛 (MDA) ,超氧化物歧化酶 (SOD)和一氧化氮 (NO)含量 ,以及尿量的观察。结果 :随休克时间的延长 ,SOD活性及NO含量逐渐下降 ,MDA ,Mg2 +含量 ,ACP活性却增高 ,再灌注发生后 ,这种改变更明显 (P <0 .0 1)。治疗组 ,则能明显减缓这种趋势 ,各项指标改善 ,且尿量增加 ,休克向有利方向发展。结论 :PNS对失血性休克晚期家兔有一定保护作用 ,机制可能与抗缺血 /再灌注损伤和NO含量增加有关
Objective: To study the therapeutic effect of Sanqi injection on hemorrhagic shock in rabbits and its mechanism. METHODS: Sixteen rabbits were randomly divided into two groups to prepare a late hemorrhagic shock model. In the control group: after shock 120 minutes, 2 times normal saline and all blood loss were returned. Treatment group: At the beginning of expansion, intravenous infusion of Panax notoginseng (PNS) 150 mg/kg was used. The method of expansion was the same as that of the control group. The venous blood samples were drawn before shock, after 60 min of shock, and after 120 min, 60 min and 120 min of reperfusion. Acid phosphatase (ACP), magnesium (Mg2 +), malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) levels, and urine volume were observed. Results: With the increase of shock time, SOD activity and NO content gradually decreased, MDA, Mg2 + content, and ACP activity increased. After reperfusion, this change was more obvious (P < 0.01). The treatment group can significantly slow down this trend, improve various indicators, increase urine output, and develop shock in a favorable direction. Conclusion: PNS has a protective effect on late-onset rabbits with hemorrhagic shock, and the mechanism may be related to anti-ischemia/reperfusion injury and increased NO levels.