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诱导多能干细胞(induced pluripotent stem cells,i PSCs)是通过转录因子或者小分子化合物诱导体细胞形成的形态和功能类似于胚胎干细胞(embryonic stem cells,ESCs)的一类细胞,具有自我更新及多向分化潜能。由于i PSCs技术不涉及传统ESCs的伦理学问题,并且获取较为方便、快捷,使其在再生医学、疾病建模、药物筛选等方面具有突出的优势。经过一定时间的探索,发现血液细胞作为i PSCs技术的供体细胞具有很大的优势,这也推动了对血液系统疾病的深入研究。该文就血细胞在i PSCs诱导重编程技术中的应用以及i PSCs技术在血液系统疾病中的最新进展作一综述。
Induced pluripotent stem cells (iPSCs) are cells that induce the formation of somatic cells through transcription factors or small molecule compounds and are similar to those of embryonic stem cells (ESCs) with self-renewal and multiple To differentiation potential. As iPSCs technology does not involve the ethical issues of traditional ESCs, and access to more convenient and efficient, so that it has a prominent advantage in regenerative medicine, disease modeling, drug screening. After a certain period of exploration, it is found that blood cells have great advantages as donor cells for iPSCs technology, which further promotes the further study of blood system diseases. This article reviews the application of blood cells in iPSCs-induced reprogramming and the recent advances in iPSCs in hematological diseases.