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目的 :探讨氧化苦参碱对中枢神经系统的影响。方法 :采用行为药理学方法观察并测定氧化苦参碱对阈剂量和阈下剂量戊巴比妥纳催眠作用的影响 ,对小鼠外观活动和自发活动的影响及对戊四氮和最大电惊厥的影响。结果 :ip氧化苦参碱 5 0、10 0、2 0 0mg/kg小鼠自发活动抑制率分别为 5 4 3 %、43 0 %、71 0 % ,戊巴比妥钠入睡时间分别缩短 32 9%、32 9%、43 8% ,而睡眠时间分别延长 2 0 9 8%、42 1 2 %、6 86 8% ,并能明显加强阈下剂量戊巴比妥钠的催眠作用。氧化苦参碱 2 0 0、40 0mg/kgip均不能对抗戊四氮和最大电休克引起的惊厥。结论 :氧化苦参碱具有镇静、催眠等中枢抑制作用
Objective: To investigate the effect of oxymatrine on the central nervous system. METHODS: Behavioral pharmacology was used to observe and determine the effects of oxymatrine on the hypnotic effects of threshold dose and subthreshold dose of pentobarbital, the effect on appearance activity and spontaneous activity of mice, and pentylenetetrazol and maximal electroconvulsions. Impact. RESULTS: The inhibitory rate of spontaneous activity of ip oxymatrine 50, 100, 200mg/kg mice was 544%, 43.00%, 71%, respectively, and the sleep time of pentobarbital sodium shortened by 32 9 respectively. %, 32 9%, 43 8%, while sleep time was increased by 20.98%, 421.2%, and 6 868%, respectively, and the hypnotic effect of the subthreshold dose of pentobarbital sodium was significantly enhanced. Oxymatrine 200 and 400 mg/kg ip were not able to fight convulsions caused by pentylenetetrazol and maximal electroshock. Conclusion :Oxymatrine has a central inhibitory effect on sedation and hypnosis