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目的:探讨CT引导下经皮肺穿刺活检术在肺部占位性病变中的诊断效率及并发症发生情况、原因及预防等。方法:回顾性分析2016年1月至2019年4月在应急总医院肿瘤内科CT引导下经皮肺穿刺活检术的134例患者临床资料。SPSS 20.0统计软件分析诊断效率及其与性别、年龄、病灶位置、病灶长径、穿刺体位及针道深度等的相关性，同时对并发症相关因素进行分析，提出预防并发症出现的注意事项。结果:CT引导下经皮肺穿刺活检术确诊率为90.30%；并发症可见气胸及肺出血，对症治疗后均可缓解。穿刺病灶长径分为5.0 cm共3组，确诊率分别为69.2%、93.9%及87.0%，3组确诊率比较差异有统计学意义(n χ2＝6.348，n P＝0.042)。气胸与病灶长径及针道深度相关(n χ2＝6.051、8.502，n P＝0.048、0.014)。n 结论:CT引导下经皮肺穿刺活检术诊断率高，安全性有保障，通过充分细致的术前准备、术中操作及术后监测可明显减少并发症的发生。因此，CT引导下经皮肺穿刺活检术在肺部占位性病变中具有重要的临床诊断价值。“,”Objective:To discuss the diagnosis efficiency of CT-guided percutaneous lung biopsy in space occupying lesions and the situation, causes and prevention of the complications.Methods:The study retrospectively analyzed 134 patients with CT-guided biopsy from January 2016 to April 2019 in Department of Oncology, Emergency General Hospital.This research used SPSS 20.0 statistical software to analyze the diagnostic efficiency and its correlation with gender, age, lesion location, lesion length diameter, puncture position and needle track depth, and also analyzed the factors which related to complications and gave the suggestions to prevent complications.Results:The diagnostic rate was 90.30%; The complications were pneumothorax and hemorrhage which could alleviated by symptomatic treatment.The length diameter of the lesions were divided into three gooups: 5.0 cm.The diagnostic rates were 69.2%, 93.9% and 87.0%, respectively. The comparison of the diagnostic rate was statistically significant ( n χ2=6.348, n P=0.042). Pneumothorax associated with lesion size and the needle depth (n χ2=6.051, 8.502, n P=0.042, 0.014).n Conclusions:CT-guided percutaneous lung biopsy has a high diagnostic rate and a guaranteed safety.Complications could be significantly reduced through preoperative preparation, intraoperative and postoperative monitoring.CT-guided percutaneous lung biopsy has important clinical diagnostic value in space occupying lesions.