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[目的]探讨二甲双胍联合达英-35辅以促排卵治疗对多囊卵巢综合征(PCOS)患者糖脂代谢和内分泌及妊娠率的影响.[方法]90例PCOS患者随机分为观察组和对照组,对照组服用炔雌醇环丙孕酮片,观察组在对照组基础上加服二甲双胍片,两组均连续服用3个月后采用克罗米芬(CC)促排卵助孕.比较两组患者治疗前后体质量指数(MBI)、腰臀比(WHR)、糖脂代谢指标、胰岛素抵抗指数(HOMA-IR)及排卵和妊娠情况.[结果]两组治疗前各项指标比较差异无统计学意义(P>0.05);治疗后两组BMI、WHR、空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、空腹胰岛素(FINS)、HOMA-IR、雌二醇(E2)、睾酮(T)、黄体生成激素(LH)、LH/卵泡刺激素(FSH)均较治疗前明显降低(P <0.05),且观察组上述指标下降更明显(P<0.05).观察组治疗后优势卵泡、子宫内膜厚度显著高于对照组(P<0.01);排卵率73.33%、妊娠率57.78%也均明显高于对照组的53.33%、35.56%(P 0.05).After treatment,BMI,waist hip ratio (WHR),fasting plasma glucose (FPG),triglyceride (TG),total cholesterol (TC),fasting insulin (FINS),insulin resistance index (HOMA-IR),estradiol (E2),testosterone (T),luteinizing hormone(LH)and LH/follicle stimulating hormone(FSH)in the two groups were sig-nificantly lower than those before treatment(P <0.05).After treatment,the above indices in the treatment group were sig-nificantly lower than those in the control group (P <0.05).On the other hand,after treatment,the dominant follicles and endometrial thickness of the treatment group were significantly higher than those of the control group(P<0.01),and the o-vulation rate and pregnancy rate (73.33%,57.78%,respectively)were significantly higher than those in the control group (53.33%,35.56%,respectively)(P <0.05).[Conclusion]Insulin sensitizer combined with anti-androgens can help to re-lieve the IR and endocrine disorders,and significantly improve the ovulation rate and pregnancy rate in patients with PCOS.