生长激素释放因子(GRF)是下丘脑内刺激腺垂体生长激素(GH)释放的激素,1983年已在大鼠下丘脑提纯,确定了其化学结构,并人工合成以及进行了放免测定。在整体动物曾发现,可乐宁(α_2受体激动剂)可引起 GH 释放增加,这一作用不受生长抑素免疫中和的影响;心得安(β受体阻断剂)亦可刺激 GH释放。在 GRF 已被阐明的情况下,日本京都大学 Y.Kabayama 等试图在离体水平观察肾上腺素能物质对 Growth hormone releasing factor (GRF), a hormone that stimulates the release of adenohypophylangioid growth hormone (GH) in the hypothalamus, has been purified from the hypothalamus of rats in 1983 to determine its chemical structure, synthesis and radioimmunoassay. It has been found in whole animals that clonidine (an alpha-2 receptor agonist) can cause an increase in GH release independent of somatostatin immunosuppression; propranolol (a beta blocker) can also stimulate GH release . In the case of GRF has been clarified, Y. Kabayama and others at Kyoto University in Japan tried to observe adrenergic substances ex vivo