大叶柴胡(Bupleurum longiradiatumTurcz.)系伞形科多年生草本植物。我省资源丰富,常做柴胡(Bupleurum chinense DC.)代用品入药。近年,我省有的中药厂用大叶柴胡配制丸、散剂,临床服用发生中毒及死亡。为查明大叶柴胡毒性成分,实验用蛙、小鼠、豚鼠,比较了柴胡和大叶柴胡及其石油醚、氯仿、乙醚、乙酸乙酯、无水乙醇、无水甲醇、水煎剂和总挥发油八种提取物的急性毒性。蛙、小鼠、豚鼠的大叶柴胡急性中毒均表现为痉挛等中枢兴奋症状,与临床急性中毒表 Bupleurum longiradiatum Turcz. is a perennial herb of the Umbelliferae family. Our province is rich in resources and we often use Bupleurum chinense DC. as a substitute for medicine. In recent years, traditional Chinese medicine factories in our province have used pellets of Bupleurum chinense to prepare pills and powders, which have been poisoned and died during clinical use. In order to ascertain the toxic components of Bupleurum chinense, frogs, mice, and guinea pigs were used in experiments to compare Bupleurum chinense and Bupleurum chinense and its petroleum ether, chloroform, ethyl ether, ethyl acetate, anhydrous ethanol, anhydrous methanol, and water. Acute toxicity of eight extracts of decoction and total volatile oil. Acute poisoning of Bupleurum chinense in frogs, mice, and guinea pigs all manifested as central stimulant symptoms such as spasticity, and clinical acute poisoning