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目的研究未经治疗的非痴呆帕金森病(PD)患者记忆功能障碍和事件相关电位的特点及其相关性。方法于2004年9月至2006年9月取第三军医大学大坪医院就诊的非痴呆PD患者共46例作为1组,所有的PD患者均未经过系统治疗;以年龄、性别及受教育程度相匹配的社区健康老年人为对照组(2组)。进行整体认知功能、韦氏记忆量表和事件相关电位P300测验。结果1组记忆商(MQ)下降,短时记忆和长时记忆明显下降,与正常对照组差异有极显著性(P<0.01),瞬时记忆无损伤,差异无显著性(P>0.05),Fuid物体记忆测验(FOM)和快速语词测验(RVR)都有损伤,差异有极显著性(P<0.01),P300潜伏期延长(360.59±26.05)ms,与正常对照组差异有极显著性(P<0.01)。结论未经治疗的早期帕金森病患者长时记忆和短时记忆均有损伤,P300潜伏期改变与记忆障碍相关。
Objective To investigate the characteristics and correlations of memory dysfunction and event-related potentials in untreated non-demented Parkinson’s disease (PD) patients. METHODS: From September 2004 to September 2006, 46 patients with non-dementia PD who were admitted to Daping Hospital of the Third Military Medical University were enrolled in this study. All PD patients were untreated. All patients were divided into three groups according to their age, sex and educational level The matched healthy community of the community as a control group (2 groups). Overall cognitive function, Wechsler memory scale and event-related potentials P300 test. Results The number of memory (MQ) decreased, the short-term memory and long-term memory decreased remarkably in Group 1 (P <0.01), but no significant difference in transient memory (P> 0.05) Fuid object memory test (FOM) and rapid verbal test (RVR) all had injury, the difference was significant (P <0.01), P300 latency was prolonged (360.59 ± 26.05) ms, which was significantly different from the normal control group <0.01). Conclusions Long-term memory and short-term memory are impaired in untreated patients with early-stage Parkinson’s disease. Changes in P300 latency are associated with impaired memory.