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目的研究子宫血管周上皮样细胞肿瘤的病理学特征、诊断、鉴别诊断和生物学行为。方法对5例子宫血管周上皮样细胞肿瘤进行常规组织学和免疫组织化学(SP 法)染色和观察,对患者进行随访,并复习相关文献。结果光镜下5例肿瘤均由透明或嗜酸细胞巢或宽窄不等的细胞索组成,间质有丰富的小血管和程度不等的透明变。免疫组织化学染色示5例瘤细胞均黑色素细胞标记阳性和程度不等的结蛋白和平滑肌肌动蛋白(SMA)阳性,CK 和 CD10阴性。5例患者现均存活。结论子宫血管周上皮样细胞肿瘤具有较特征性的组织病理及免疫组织化学特点,HMB45阳性对诊断有重要作用。该肿瘤分良生、恶性潜能不能确定和恶性三类,应与透明细胞癌和上皮样平滑肌肿瘤区别。
Objective To study the pathological features, diagnosis, differential diagnosis and biological behavior of uterine pericytes. Methods Five cases of uterine perineural epithelioid cell tumor were stained and observed by routine histology and immunohistochemistry (SP method). The patients were followed up and the related literatures were reviewed. Results In the light microscope, all the 5 tumors were composed of transparent or eosinophilic nests or cell strands with different widths. The stroma was rich in small blood vessels and varying degrees of transparency. Immunohistochemical staining showed that all of the 5 cases of tumor cells had positive and varying levels of melanophores labeled with desmin and smooth muscle actin (SMA) positive and CK and CD10 negative. Five patients are now alive. Conclusion Uterine perivascular epithelioid cell tumor has the characteristics of histopathology and immunohistochemical features, HMB45 positive for the diagnosis of an important role. The tumor benign, malignant potential can not determine the three categories and malignant, clear cell carcinoma and epithelial smooth muscle tumors should be distinguished.