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目的 研究纤维粘连蛋白 (FN)在乳腺浸润性癌中的表达及其与同侧腋窝淋巴结转移的关系。方法 应用免疫组化 (SP)法检测 5 0例浸润性癌中基底膜及间质FN的表达。结果 癌巢周围基底膜FN的表达与癌细胞分化程度及淋巴结转移有关 ,而间质FN的表达与以上二者均无关。结论 癌巢周围基底膜FN的表达对乳腺癌预后评估有意义。
Objective To study the expression of fibronectin (FN) in breast invasive carcinoma and its relationship with ipsilateral axillary lymph node metastasis. Methods Immunohistochemistry (SP) was used to detect the expression of basement membrane and interstitial FN in 50 cases of invasive carcinoma. Results The expression of FN in the basement membrane around cancer nests was related to the degree of cancer cell differentiation and lymph node metastasis. However, the expression of interstitial FN was not related to the above two. Conclusion The expression of FN in the basement membrane of cancer nests is significant for the prognosis evaluation of breast cancer.