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合成一些促黄体素释放激素(LHRH)的拮抗性类似物,其最终目的是用于妇女达到阻断排卵。最近报告合成了一组具有11个氨基酸的肽,这是一组强的LHRH的拮抗性类似物。其中之一为〔焦谷脯~1〕〔D-苯丙~2〕〔D-色~(3、6)〕-LHRH,已证明给大鼠应用该拮抗物(200μg/每鼠)能100%抑制排卵。作者在恒河猴观察了该拮抗物的阻断排卵作用并比较了用药时间与效力的关系。选用6只月经周期正常的健康恒河猴进行实验,3只给药,另3只作为对照。根据该繁殖群的猴正常中期促性腺激素峰平均为第十一天,以及基于测定血清雌二醇浓度,在月经周期的第七天以
Antagonistic analogues of luteinizing hormone releasing hormone (LHRH) have been synthesized for the ultimate goal of blocking ovulation in women. A recent report has synthesized a set of peptides with 11 amino acids, a group of potent LHRH antagonistic analogs. One of them is [Gorgon ~ 1] [D-phenylpropane-2] [D-color ~ (3,6)] - LHRH and the antagonist (200 μg / rat) % Inhibition of ovulation. The author observed in Rhesus monkeys blocking the ovulation of the antagonist and compared the time and efficacy of the relationship. Six healthy rhesus monkeys with normal menstrual cycle were selected for experiment, three were given, and the other three were used as control. The normal monkey gonadotropin peak according to this breeding herd was on the 11th day on average, and on the seventh day of the menstrual cycle based on the measurement of serum estradiol concentration