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由于病毒和宿主之间有微妙的平衡,因此发展抗病毒感染的化学治疗药物有两种基本途径:(1)抑制病毒的复制,(2)特异性或非特异性地加强宿主的防御机制。在考虑抗病毒药物之前,了解病毒的复制是必要的。首先,病毒附着在细胞表面上的特定受体部位,然后,通过空泡形成和吞饮作用进入细胞内。在细胞内,病毒蛋白膜被除去,裸露出核酸。核酸进入细胞浆后,根据病毒是否含 RNA或 DNA 而分别在细胞浆内或在细胞核内进行复制。开始,病毒合成病毒核酸复制所必需
There are two basic approaches to develop antiviral chemotherapeutic drugs due to the delicate balance between the virus and the host: (1) inhibition of viral replication, and (2) specifically or non-specifically enhanced host defense mechanisms. Before considering antiviral drugs, it is essential to understand the virus’s replication. First, the virus attaches to a specific receptor site on the cell surface and then enters the cell through vacuolization and endocytosis. Within the cell, the viral protein membrane is removed, exposing the nucleic acid. Nucleic acid into the cytoplasm, according to whether the virus contains RNA or DNA were in the cytoplasm or in the nucleus of replication. Initially, the virus is required for viral viral replication