作者对52例人脑原发性肿瘤和5例正常人脑DNA中c-myc、L-myc、Nmyc、erbB、c-fos、sis及Ha-ras等七种癌基因的扩增和重排进行了研究,发现多数胶质瘤中有c-myc、L-myc、erbB及c-fos等癌基因的扩增,少数胶质瘤和脑膜瘤中发现myc家族癌基因的限制性酶切区带位置有多态性变化;同时还观察到原发性脑瘤中存在两种或两种以上癌基因的扩增和重排现象。作者对癌基因与人脑原发性肿瘤的关系进行了讨论。 The authors amplified and rearranged seven oncogenes including c-myc, L-myc, Nmyc, erbB, c-fos, sis, and Ha-ras in brain DNA of 52 human primary brain tumors and 5 normal human brains. A study was conducted and found that c-myc, L-myc, erbB, and c-fos genes were amplified in most gliomas, and the restriction enzyme region of myc family oncogenes was found in a small number of gliomas and meningiomas. There is a polymorphism change in the band position; at the same time, there are also observed the amplification and rearrangement of two or more oncogenes in primary brain tumors. The authors discuss the relationship between oncogenes and primary brain tumors.