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生长抑素(SS)可用于治疗多种疾病,但其半衰期短。而类似物山道抑素(SMS 201-995)的作用则强45倍,半衰期长,已用于治疗肢端肥大症,胃肠道出血,分泌性腹泻,胰腺内分泌瘤和Ⅰ型糖尿病。作者报告用该药长期皮下注射治疗牛皮癣患者9例,观察①摄入标准餐后胰岛素、胰高糖素、胰多肽(PP)的水平,以了解该药对葡萄糖代谢的影响;②治疗前、中、后TSH、T_3、T_4水平,以了解该药对甲状腺的影响;③了解该药的药物动力学。患者年龄27～48岁。患慢性牛皮癣,皮损面积≥10％体表面积。用该药前停用其它药物4周,山
Somatostatin (SS) can be used to treat many diseases, but its half-life is short. The analogous salbutamol (SMS 201-995) is 45 times more potent and has a longer half-life and has been used in the treatment of acromegaly, gastrointestinal bleeding, secretory diarrhea, pancreatic endocrine tumors and type 1 diabetes. The authors report the use of long-term subcutaneous injections of the drug in 9 patients with psoriasis, observed ① intake of standard postprandial insulin, glucagon, pancreatic polypeptide (PP) levels in order to understand the drug on glucose metabolism; ② before treatment, In the post-TSH, T_3, T_4 levels to understand the drug on the thyroid; ③ understand the drug pharmacokinetics. Patients aged 27 to 48 years old. Chronic psoriasis, skin lesions area ≥ 10% body surface area. Stop using other drugs for 4 weeks before taking this medicine