口服避孕药(OC)问世已二十余年,早在1961年就注意到,使用 OC 的一些妇女,同时患有静脉血栓,肺栓塞以及偏头痛等症状,但对此没有做出解释。以后,Walsh 于1965年报告69例使用 OC 妇女,有视觉异常(视网膜血管血栓)或偏头痛症状。六年前,美国对 OC 所引起的周边血管并发症问题进行了热烈争论,近来讨论的焦点集中在心血 Oral contraceptives (OCs) have been around for more than two decades. As early as 1961, some women who used OC were noted as having symptoms of venous thromboembolism, pulmonary embolism, and migraine, but no explanation was given. Later, Walsh reported 69 women who used OC in 1965 with visual abnormalities (retinal vascular thrombosis) or migraine symptoms. Six years ago, the United States heatedly debated the issue of peripheral vascular complications caused by OC. The focus of recent discussions has focused on