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大约40%患脑炎后和原发性巴金森氏症的患者有感觉障碍。关于巴金森氏症时的原发性感觉症状的病理学尚不知晓,但已知是基底节多巴胺能缺陷引起的。接受神经阻滞药治疗的病人常出现巴金森氏征和静坐不能,认为是药物阻断多巴胺受体所致。神经阻滞药引起的锥外综合征与脑炎后和原发性巴金森氏症具有共同的现象学、药理学和生化方面的特点。本文目的是要证实神经阻滞药诱发锥外综合征伴有原发性感觉症状这一假说。方法:收集病例107例。其中60例为接受神经阻滞药治疗者,以氟哌啶醇、三氟拉嗪和氯丙嗪为主,平均药量806mg/日(按氯
About 40% of patients with post-encephalitis and primary Parkinson’s disease have sensory disturbances. The pathology of the primary sensory symptoms at the time of Parkinson’s disease is not known, but it is known to be caused by defects in the basal ganglia dopaminergic. Patients receiving neuroblocks often have Parkinson’s symptoms and sit-ins, believed to be drugs that block dopamine receptors. Neurological block drugs caused by extrapyramidal syndrome and post-encephalitis and primary Parkinson’s disease have a common phenomenological, pharmacological and biochemical characteristics. The purpose of this paper is to confirm the hypothesis that neuroblocks induce extrapyramidal syndrome with primary sensory symptoms. Methods: 107 cases were collected. Among them, 60 patients were treated with nerve blockers, with haloperidol, trifluoperazine and chlorpromazine as the main drugs with the average dose of 806mg / day