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目的探讨心脑通络液对动脉粥样硬化兔的血清TXB2、主动脉6-Keto-PGF1a含量的影响。方法选取雄性新西兰白兔40只,随机分成5组,连续治疗3个月。结果治疗前6-Keto-PGF1a明显降低(P<0.01);高剂量组、低剂量组、血脂康组治疗三个月后,6-Keto-PGF1a水平均有升高(P<0.01);高剂量组与血脂康组疗效显著,且两组差异无统计学意义(P>0.01),高剂量组与低剂量组比较,各项指标高剂量组优于低剂量组,差异有统计学意义(P<0.05)。结论心脑通络液具有增加动脉粥样硬化兔血清6-Keto-PGF1α的含量,降低动脉粥样硬化家兔血清TXB2的作用。
Objective To investigate the effect of Xinnao Tongluo Liquid on the levels of TXB2 and aorta 6-Keto-PGF1a in atherosclerotic rabbits. Methods Forty male New Zealand white rabbits were randomly divided into five groups and treated continuously for three months. Results The levels of 6-Keto-PGF1a in high-dose group, low-dose group and Xuezhikang group were significantly decreased (P <0.01), and the levels of 6-Keto- Compared with the low-dose group, the high-dose group and the low-dose group had better effects than the low-dose group (P> 0.01), the difference was statistically significant (P> P <0.05). Conclusions Xinnaotongluo Decoction can increase the serum 6-Keto-PGF1α level in atherosclerotic rabbits and decrease the level of TXB2 in atherosclerotic rabbits.