【目的】从维生素A稳态角度探讨职业接触二噁英可能对男性造成的健康影响,为二噁英的皮肤毒性作用及作用机制提供依据和线索。【方法】采用微量荧光法和ELISA方法分别测定人群血浆中维生素A的含量和视黄醇结合蛋白的浓度。【结果】与对照组相比,暴露组血浆中维生素A含量有所升高但没有统计学意义(P>0.05),而视黄醇结合蛋白的水平出现明显的上升且具有统计学意义(P<0.01)。【结论】职业性接触二噁英对男工血浆中维生素A及视黄醇正常水平具有一定的干扰作用。 【Objective】 To investigate the possible effect of occupational exposure to dioxin on males from the perspective of vitamin A stability and to provide basis and clues for the skin toxicity and mechanism of dioxin. 【Method】 The content of vitamin A and the concentration of retinol binding protein in plasma were determined by micro-fluorescence and ELISA respectively. Results Compared with the control group, the plasma vitamin A level in the exposed group was increased but not statistically significant (P> 0.05), while the retinol binding protein level was significantly increased (P <0.01). 【Conclusion】 Occupational exposure to dioxins may interfere with the normal level of vitamin A and retinol in plasma of male workers.