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目的:探讨静脉注射重组人脑利钠肽对急性心肌梗死伴心力衰竭患者的急性血流动力学效应。方法:选取2011年6月至2013年5月我院收治的急性心肌梗死伴心力衰竭患者60例进行分析,按照治疗方法分成观察组和对照组两组,每组30例,观察组采用静脉注射重组人脑利钠肽治疗,对照组采用静脉注射硝酸甘油治疗,观察两组治疗前后血流动力学指标变化。结果:两组治疗后2h、12h心率(HR)、肺小动脉契压(PCWP)和心脏指数(CI)均有显著改善(P<0.05),且观察组改善水平明显优于对照组(P<0.05);三个指标停药后6h均恢复到治疗前水平。结论:静脉注射重组人脑利钠肽治疗急性心肌梗死伴心力衰竭患者具有较好的急性血流动力学效应,安全可行。
Objective: To investigate the acute hemodynamic effects of intravenous administration of recombinant human brain natriuretic peptide in patients with acute myocardial infarction and heart failure. Methods: Sixty patients with acute myocardial infarction and heart failure admitted to our hospital from June 2011 to May 2013 were selected and divided into two groups according to the treatment: observation group and control group, 30 cases in each group. Intravenous injection Recombinant human brain natriuretic peptide treatment, the control group was treated with intravenous nitroglycerin, the changes of hemodynamics before and after treatment were observed. Results: The heart rate (HR), PCWP and CI of both groups were significantly improved at 2h and 12h (P <0.05), and the improvement in the observation group was significantly better than that in the control group (P <0.05). All three indexes returned to their pretreatment levels 6h after withdrawal. Conclusion: Intravenous injection of recombinant human brain natriuretic peptide has a better acute hemodynamic effect in patients with acute myocardial infarction and heart failure, which is safe and feasible.