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目的:观察晕海宁对肝动脉灌注化疗栓塞术后恶心、呕吐的疗效及不良反应。方法:将126例行肝动脉灌注化疗栓塞治疗的原发性肝癌患者随机分为3组各42例;A组术前口服晕海宁,B组、C组在术中未灌注化疗药物前肝动脉内分别注射格拉司琼,甲氧氯普胺;观察术后恶心、呕吐发生率及药物不良反应。结果:A,B组分别与C组比较,术后恶心、呕吐发生率差异有统计学意义(P<0.05);A,B组间差异无统计学意义(P>0.05)。C组4例发生药物不良反应。结论:晕海宁对防治肝癌肝动脉灌注化疗栓塞术后恶心、呕吐疗效好,不良反应轻,且价格低廉,有可能成为治疗肝癌肝动脉灌注化疗栓塞术后恶心、呕吐的一线方案。
Objective: To observe the curative effect and adverse reactions of Halium on nausea and vomiting after hepatic arterial chemoembolization. Methods: A total of 126 patients with primary hepatocellular carcinoma who underwent hepatic arterial chemoembolization were randomly divided into three groups (n = 42). Group A received halo Haining, group B, and group C before operation. Were given granisetron, metoclopramide; observed postoperative nausea and vomiting incidence and adverse drug reactions. Results: The difference of postoperative nausea and vomiting between group A and group B was statistically significant (P <0.05). There was no significant difference between group A and group B (P> 0.05). C group 4 cases of adverse drug reactions occurred. Conclusion: Halide Hain on the prevention and treatment of hepatic artery chemoembolization after hepatic artery chemoembolization nausea, vomiting good effect, light adverse reactions, and low prices, may become a liver cancer hepatic artery chemoembolization nausea and vomiting after a first-line program.