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The etectrophysiologic effects of the new antiarrhythmic agent, propafenone, were investigated in 10 mongrel nascent canine, ages 5 to 11 days. Utilizing standard His bundle recording and stimulation techniques, assessments of sinus and atrioventricular (AV) node function and atrial, AV nodal and ventricular refractory periods were performed prior to(control) and after cumulative intravenous doses of 1,2 and 4 mg/kg of propafenone. Propafenone depressed the spontaneous heart rate and prolonged the post atrial pacing recovery times.AV nodal function was depressed as manifested by Wenckebach periodicity occurring at slower pacing rates, increases in AV nodal conduction time and increases in AV nodal refractoriness. Atrial and ventricular refractory periods were prolonged significantly in a dose dependent fashion, Prolongation of the His-Purkinje conduction time occurred at the highest dose. Thus, propafenone exerts a generalized depressant effect on nascent myocardial conduction and refractoriness which suggests that this agent may be useful in the therapy of atrial ann ventricular dysrhythmias in the immature heart.
The etectrophysiologic effects of the new antiarrhythmic agent, propafenone, were investigated in 10 mongrel nascent canine, ages 5 to 11 days. Utilizing standard His bundle recording and stimulation techniques, assessments of sinus and atrioventricular (AV) node function and atrial, AV nodal and ventricular refractory periods were performed prior to (control) and after cumulative intravenous doses of 1,2 and 4 mg / kg of propafenone. Propafenone depressed the spontaneous heart rate and prolonged the post atrial pacing recovery times. AV nodal function was depressed as manifested by Wenckebach periodicity occurring at slower pacing rates, increases in AV nodal conduction time and increases in AV nodal refractoriness. Atrial and ventricular refractory periods were prolonged significantly in a dose dependent fashion, Prolongation of the His-Purkinje conduction time occurred at the highest dose. Thus , propafenone exerts a generalized depressant effect on nascent myocardial conduction and refr actoriness which suggests that this agent may be useful in the therapy of atrial ann ventricular dysrhythmias in the immature heart.