2,2′,4,4′-四溴联苯醚(tetra-brominated diphenyl ethers,BDE-47)是环境样品及生物组织中含量最高的PBDEs同系物之一,具有多方面的健康危害作用.本文简要介绍BDE-47的理化性质、主要暴露途径及人体组织含量水平,并对其内分泌干扰毒性、神经毒性、肝脏毒性、生殖毒性及免疫毒性等作了归纳与总结.结果表明,对BDE-47环境毒理学的研究缺乏系统性和深入性.为此,一方面可从其各种毒性作用之间的关联入手,另一方面可引入医学与生命科学的新技术与研究策略,全面深入地研究其生物毒性机制. Tetrabromodiphenyl ethers (BDE-47) is one of the most potent PBDEs in environmental samples and biological tissues and has many health hazards. In this paper, the physicochemical properties, main routes of exposure and the content of human tissue of BDE-47 were briefly introduced, and its endocrine disrupting toxicity, neurotoxicity, hepatotoxicity, reproductive toxicity and immunotoxicity were summarized and summarized.The results showed that BDE- 47 The lack of systematic and in-depth research on environmental toxicology, on the one hand, can start with the connection between its various toxicological roles and on the other hand can introduce new technologies and research strategies in medicine and life sciences, Study its biological toxicity mechanism.