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目的:探讨鼻神经内分泌癌的临床表现、治疗方法及预后。方法:回顾性分析四川大学华西医院2009-02-2012-02期间收治的8例鼻神经内分泌癌患者的临床资料。结果:3例原发于上颌窦,其中2例分别于术后8个多月及14个多月死亡,1例随访至今10个多月仍存活。原发于鼻腔5例,1例在随访至7个多月时复发,行放疗后,已随访20个多月,未见局部及远处转移;余4例,分别随访13、20、27、28个多月,未见复发。结论:本病发病率较低,临床表现及预后与发病部位有关,诊断主要取决于组织病理学表现、免疫组化结果及电镜下超微结构特征;需与低分化鳞癌、黑色素瘤及嗅神经母细胞瘤鉴别;早期诊断和综合治疗是提高本病生存率的关键。
Objective: To investigate the clinical manifestations, treatment and prognosis of nasal neuroendocrine carcinoma. Methods: The clinical data of 8 patients with nasal neuroendocrine carcinoma who were admitted to West China Hospital of Sichuan University during 2009-02-2012-02 were retrospectively analyzed. Results: Three cases were found in the maxillary sinus. Two of them died after more than 8 months and more than 14 months respectively. One case survived more than 10 months after the visit. Primary nasal cavity in 5 cases, 1 case of recurrence in the follow-up to more than 7 months after radiotherapy, has been followed up for more than 20 months, no local and distant metastasis; the remaining 4 cases were followed up 13,20,27, More than 28 months, no recurrence. Conclusion: The lower incidence of this disease, clinical manifestations and prognosis of the site of the disease, the diagnosis depends on histopathological findings, immunohistochemistry and ultrastructure of electron microscopy; need to differentiate with poorly differentiated squamous cell carcinoma, melanoma and olfactory Neuroblastoma identification; early diagnosis and comprehensive treatment is to improve the survival rate of the key.