Isolation of a new structured acousto-optic switch based on an integrated optical polarization-independent quasicollinear acousto-optic tunable filter is studied in detail. The factors that influence the isolation of the optical switch are analysed, the expressions of the isolation are educed, and the isolation of the device is measured in experiment. It is found that the isolation mainly depends on the TE/TM mode intensity ratio, the mode-splitter extinction rate, and the conversion efficiency.