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雄性SD大鼠,在其杏仁核埋置电极,每日一次用双相方波电流(400μA,60Hz、1s)刺激,直至获得连续5个5级或以上的运动惊厥为完全点燃。同时观察行为和脑皮层放电,停止处理后四周再行电测试,以检测动物是否仍处点燃状态。结果:完全点燃率为80%(96/120)。脑组织学证实电极全部位于杏仁核,大鼠惊厥行为与脑电异常同步,停止处理四周后,大鼠仍处最高等级惊厥状态。提示杏仁核点燃模型确是稳定可靠的模拟人类癫痫的理想动物模型。
Male SD rats were implanted with electrodes in the amygdala and stimulated with two-phase square wave current (400μA, 60Hz, 1s) once a day until five consecutive motor convulsions of grade 5 or above were completely ignited. At the same time observe the behavioral and cerebral cortex discharge, stop treatment four weeks after the electrical test again to detect whether the animals are still lit. Result: The complete firing rate was 80% (96/120). Brain histology confirmed that the electrodes were all located in the amygdala, and convulsions in rats were synchronized with abnormal EEG. After four weeks of treatment, the rats remained in the highest grade of convulsions. Suggesting that the amygdala lighting model is indeed a stable and reliable ideal animal model of human epilepsy simulation.