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目的:观察并比较18α-、18β-甘草酸(GL)及其不同配比物的抗炎作用。方法:制备小鼠和大鼠急性炎症模型,观察18α-、18β-GL及其不同配比物对二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足跖肿胀和四氯化碳致大鼠急性肝损害的影响,并对其抗炎作用进行比较。结果:小鼠耳肿胀实验显示α-与β-GL比例为3∶7时对耳肿胀有抑制作用,在抑制角叉菜诱发的大鼠足肿胀实验中,氢化可的松组与α-、β-GL比例为5∶5,4∶6和3∶7能明显抑制足肿胀。各给药组均能提高四氯化碳致肝脏损害后的血清白细胞介素-6(IL-6)水平,并且β-GL和4∶6,3∶7配比组提高明显。结论:α-、β-GL抗炎效果存在着差异,并且不同比例的两者配比物所表现出来的抗炎能力随着比例的改变而改变。α-GL和β-GL比例为4∶6与3∶7体现出较强的抗炎效果,有开发成新一代甘草酸制剂的潜力。
Objective: To observe and compare the anti-inflammatory effects of 18α-, 18β-glycyrrhizic acid (GL) and its different ratios. METHODS: Acute inflammation models in mice and rats were prepared to observe the effect of 18α-, 18β-GL and its different proportions on xylene-induced mouse ear swelling, carrageenan-induced rat paw swelling, and carbon tetrachloride induced. The effects of acute liver damage in rats and their anti-inflammatory effects were compared. RESULTS: Mouse ear swelling experiments showed that the ratio of α- and β-GL was 3:7, which had inhibitory effect on ear swelling. In the experiment of inhibiting foot swelling induced by chondrus, hydrocortisone group and α-, The ratio of β-GL 5:5, 4:6, and 3:7 significantly inhibited foot swelling. Each administration group could increase serum interleukin-6 (IL-6) level after liver damage caused by carbon tetrachloride, and the β-GL and 4:6, 3:7 ratio group increased significantly. Conclusions: There are differences in the anti-inflammatory effects of α- and β-GL, and the anti-inflammatory capacity demonstrated by the ratio of the two components will change with the change of proportion. The ratios of α-GL and β-GL of 4:6 and 3:7 exhibit strong anti-inflammatory effects, and they have the potential to be developed into a new generation of glycyrrhizic acid preparations.