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目的探讨急性冠脉综合征患者炎症因子的变化及临床意义。方法选择84例急性冠脉综合征患者,用ELISA或放免分析法对其血清中C反应蛋白(CRP)、血浆内皮素-1(ET1)、OX-LDL免疫复合物及肿瘤坏死因子α(TNF-α)、可溶性血管细胞间粘附分子1(sVCAM-1)、白细胞介素1(IL-1β)水平进行了测定。并与30例正常对照组比较。结果急性冠脉综合征患者血清CRP、OX-LDL-IC、IL-1β、TNF-α及sVCAM-1浓度明显升高于正常对照组(P<0.01)。结论急性冠脉综合征患者体内血清有多种细胞因子水平增高,提示炎症与急性冠脉综合征的发病有关。
Objective To investigate the changes and clinical significance of inflammatory factors in patients with acute coronary syndrome. Methods Eighty-four patients with acute coronary syndrome were enrolled in this study. Serum levels of C-reactive protein (CRP), plasma endothelin-1 (ET1), OX-LDL immune complex and tumor necrosis factor-α -α), soluble vascular cell adhesion molecule 1 (sVCAM-1), interleukin-1 (IL-1β) levels were measured. And compared with 30 normal control group. Results Serum levels of CRP, OX-LDL-IC, IL-1β, TNF-α and sVCAM-1 in patients with acute coronary syndrome were significantly higher than those in normal controls (P <0.01). Conclusion There are many cytokines in the serum of patients with acute coronary syndrome, suggesting that inflammation is related to the pathogenesis of acute coronary syndrome.