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采用共组装法成功制备了电中性疏水抗癌药物喜树碱(CPT)/氧化石墨烯(GO)/Mg-Al类水滑石(HTlc)纳米杂化物.先将CPT负载于荷负电的GO纳米片表面上制备成CPT/GO复合物,再与荷正电的HTlc纳米片(HNS)共组装,形成CPT/GO/HTlc纳米杂化物,其中GO纳米片和HNS相间叠加,CPT负载于层间.采用X-射线衍射、透射电子显微镜、原子力显微镜、扫描电子显微镜-能量色谱仪、傅里叶变换红外光谱、紫外-可见分光光度计和热重/差示扫描量热分析等技术对纳米杂化物进行了表征.37℃下分别在pH 7.4和4.0的磷酸缓冲液中,考察了CPT/GO/HTlc纳米杂化物的药物释放行为.结果表明,CPT/GO/HTlc纳米杂化物的药物释放过程符合准二级动力学方程,且具pH响应性,在酸性(pH4.0)介质中的释放速率和释放率明显高于中性(pH 7.4)介质.共组装法是构筑药物/GO/HTlc纳米杂化物的简便方法,该纳米杂化物在药物输送领域具有良好的应用前景.
Successful electrically neutral hydrophobic anticancer drug camptothecin (CPT) / graphene oxide (GO) / Mg-Al hydrotalcite (HTlc suspension) nanohybrid were prepared by co-assembly method. First CPT supported negatively charged GO CPT / GO composites were prepared on the surface of nanosheets and then co-assembled with positively charged HTlc nanosheets (HNS) to form CPT / GO / HTlc nanocomposites. X-ray diffraction, transmission electron microscopy, atomic force microscopy, scanning electron microscopy - energy chromatograph, Fourier transform infrared spectroscopy, UV-visible spectrophotometer and thermogravimetry / differential scanning calorimetry The drug release behavior of CPT / GO / HTlc nanocomposites was investigated in phosphate buffered saline at pH 7.4 and pH 4.0 at 37 ℃ .The results showed that the drug release of CPT / GO / HTlc nanocomposites The process was in accordance with quasi-second order kinetic equation with pH-responsiveness, and its release rate and release rate in acidic medium (pH4.0) were significantly higher than those in neutral medium (pH 7.4) HTlc nano-hybrids in the field of drug delivery Good prospects.